Life Extension - Zinc L-carnosine guards against NSAID damage
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The nutritional supplement zinc L-carnosine protects the upper-gastrointestinal tract against damage often caused by the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (Indocin[R]), according to a recent report. *
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The use of NSAIDs such as ibuprofen (Advil[R]), naproxen (Aleve[R], Naprosyn[R]), and piroxicam (Feldene[R]) is often limited by their adverse gastrointestinal effects, including stomach ulcers and upper-gastrointestinal bleeding. Sold as a prescription ulcer medication in Japan, zinc L-carnosine supports gastrointestinal healing.
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In an animal model of indomethacin- and stress-induced upper-gastrointestinal damage, oral zinc L-carnosine decreased stomach injury by 75% and small intestinal injury by 50%. While adult volunteers who took indomethacin (50 mg, three times daily) for five days had increased gut permeability–a pathological change that may contribute to inflammation–no significant increase in intestinal permeability was seen when zinc L-carnosine (37.5 mg, twice daily) was co-administered. People who take NSAIDs may thus be able to guard their gastrointestinal health using supplemental zinc L-carnosine.
Reference
* Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007 Feb;56(2):168-75.
–Elizabeth Wagner, ND
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COPYRIGHT 2008 Gale, Cengage Learning
